¹Dr Mais Mamoon, ¹Dr Alaq Khalid,

¹Thumbay Ajman Hospital

Background(s): 

• T1DM or autoimmune diabetes is a complex, chronic autoimmune disease with a serious clinical impact and the incidence is increasing, as shown from studies in several counties.
• The most popular hypothesis circulating within the scientific community is that viral infections enhance or elicit autoimmune disorders such as type 1 diabetes.
• Viruses can trigger and promote pancreatic islet cell destruction and cause type 1 diabetes mellitus (T1DM).
• Type 1 diabetes (T1D) in children and particularly in teenagers and adults is strongly associated with auto reactivity to the Mr 65,000 isoform of glutamic acid decarboxylase (GAD65). Autoantibodies to GAD65 are common at the time of clinical diagnosis and may be present for years prior to the onset of hyperglycemia.
• GAD65 autoantibodies predict conversion to insulin dependence when present in patients classified with type 2 diabetes nowadays more often referred to as patients with latent autoimmune diabetes in the adult (LADA). GAD antibodies belong to a group of diabetes-associated antibodies that instruct the immune system to destroy the insulin-producing pancreatic cells. GAD latent autoimmune diabetes in adults (LADA)
• Patients with COVID-19 present with variety of clinical presentations ranging from no symptoms or mild illness to critical illness with multi-organ failure even death.

OBJECTIVE

• Highlight the possibility of induction of acute onset

Method(s): Highlight the possibility of induction of acute onset of DM after COVID infection which need to be more investigated and considered by physicians treating patent with high levels of blood glucose and its complications following COVID 19 infection.

Result(s): Patient showed high Anti ccp titer which can raised the incidence of overlapped autoimmune disease after COVID 19 infection

Conclusion(s): Genetic associations between TYpe I DM and other autoimmune disease